表現データベース


  • ADMA level - lipophilic, hydrophilic

    Additionally, ADMA levels in the lipophilic group were significantly lower than those in the non-statin and hydrophilic groups.

  • Amelioration

    Drug A (3 mg/kg/day) clearly ameliorated this periostitis and bone destruction (Fig. 5C), whereas Drug B induced no obvious effect (Fig. 5D).

  • Ang II

    This result conclusively shows that, on bone marrow-derived cells, the receptor is not required for peripheral blood erythrocytosis to be induced by Ang II.

    These bone marrow transplantation results implied that the erythrocytosis induced by Ang II is due mainly to the stimulation of AT1aR present in the recipient organs, such as on kidney or liver cells.

    First, we determined which Ang II receptor subtypes are expressed by the spleen and bone marrow cells of wild-type (WT) mice.

  • Binding motifs - transcription factor

    Several binding motifs for potent transcription factor NF-IL6 were located adjacent to each NF-κB site

  • Bone disorganization - radiography

    As shown in Figs. 5 and 6, radiography of the hind limb from the vehicle-treated group showed severe disorganization (periostitis and destruction) of bone in the distal tibia, tarsus, metatarsus and calcaneus (Fig. 5B).

  • bone marrow cells

    Recipient female mice aged 8 or 9 weeks were lethally irradiated and divided into two groups. One group received bone marrow cells from male donor WT mice (designated as X<-WT), and the second received cells from male donor angiotensin II type 1a receptor-deficient mice (AT1-KO) (designated as X<-AT1-KO). As a control, irradiated female WT mice also received bone marrow cells from male donor WT mice (designated as X<-WT).

  • bone marrow transplant

    To evaluate how end-organ damage is affected by AT1 activity in BMDCs, we conducted bone marrow transplantation (BMT) experiments as described previously (31).

    These bone marrow transplantation results implied that the erythrocytosis induced by Ang II is mainly due to the stimulation of AT1aR present in the recipient organs, such as on kidney or liver cells.

  • Cervical lymph node metastases - olfactory neuroblastoma

    Of the 12 patients with olfactory neuroblastoma, five experienced recurrent episodes of the disease, three had intracranial invasion, one had cervical lymph node metastases, one had distant metastases, and two were considered to be in Kadish stage B.

  • Chemotherapy -  toxicity

    Chemotherapy-related toxicity was graded according to the National Cancer Institute Common Toxicity Criteria version 2. The most common grade 3 or 4 toxicities were leucopenia (33%), neutropenia (50%), febrile neutropenia (8%) and diarrhea (25%), all of which were manageable.

  • Death - due to treatment

    None of the seven patients died as a result of treatment, nor did they suffer any severe toxic side effects due to irradiation, such as vision impairment, brain necrosis, etc. This lack of side effects notwithstanding, ongoing follow-up must be performed.

  • Follow-up period

    The median follow-up period for survivors was 22.2 months (range: 14.8 - 63 months).

  • Frequency - decreased

    Drug A (1 mg/kg/day) and Drug B (3 mg/kg/day) significantly decreased the frequency of incidence compared with the vehicle-treated group (Fig. 2)

  • Gene sequence deletion - NF-κB

    Further deletion between -208 and -188 (Δ-208Luc and Δ-188/Luc), which resulted in the loss of the tandem repetition of NF-κB sequences at the pκB1 site, entirely abolished both basal activity and lipopolysaccharide inducibility.

  • Groups - drug-treated

    No differences between the vehicle-treated and drug-treated groups were seen.

  • Histological evaluation

    During histopathological evaluation, none of the animals exhibited catastrophic degradation in any group. In the vehicle-treated group, relatively severe injuries, such as fibrin deposition and infiltration of neutrophils was seen in the synovium (data not shown).

  • IL-6 and IFN-γ - activation of NF-IL6, STAT3, and STAT1

    IL-6 and IFN-γ, which activate NF-IL6, STAT3, and STAT1 [34, 35], were unable to increase hBD-2 promoter activity in RAW 264.7 cells transfected with the hBD2/Luc plasmid.

  • In vitro assay

    In contrast, compound X dose-dependently inhibited both recombinant human COX-1 and COX-2 in all three in vitro assays.

  • Inclusion criteria

    Animals with lymphoid tissue lesions failed to meet the inclusion criteria and were excluded from the count.

  • Increased frequency

    Vocalization frequency increased significantly in the vehicle-treated AIA group compared with the normal group.

  • Infection - age strata

    In the hospital in question, infection was frequent in the 40-49 age strata (p = 0.015).

  • Inhibition

    In the PGE2 ELISA and peroxidase assay, compound X hardly inhibited COX-1 and COX-2 at all.

    Since platelets do not express COX-2, TXB2 production from whole blood platelets was used as a measure of COX-1 inhibitory activity.

  • Inhibition - dose-dependent

    Compound X inhibited PGE2 dose-dependently in the exudates.

    Compound X inhibited carrageenan-induced edema in a dose-dependent manner.

    In contrast, compound X dose-dependently inhibited both recombinant human COX-1 and COX-2 in all three in vitro assays.

  • Macrophage-like cell line - RAW 264.7 -  transient transfection

    These constructs were then transiently transfected into the RAW 264.7 macrophage-like cell line.

  • Metastatic disease

    The median survival period for the 6 out of 12 patients with recurrent or distant metastatic disease was 16.1 months (Figure 3).

  • Optimal treatment - cancer patients

    Together, these reports suggest that the optimal treatment for surgically resectable cases is surgery followed by adjuvant radiation therapy.

  • Outbreak - rate of spread

    If an outbreak was simply allowed to continue spreading under these conditions, the results showed that approximately 50 to 90 symptomatic cases would occur by Day 30.

  • Patient age

    The median age of patients was 39 years (range: 17-63 years). 

    The treatment response rate was 75% (3/4) in the group aged less than 50 years, but 0% (0/8) in those over 50 (P = 0.018). 

  • Patient characteristics

    The characteristics of the 43 patients (29 males and 14 females) included in the study are summarized in Table I.

  • Paw volume

    Drug A and Drug B decreased paw volume in a dose-dependent manner in rats.

  • Phylogenetic tree

    A phylogenetic tree was constructed by the NJ method to investigate genetic relationships among the 20 partial sequences of 16S rRNA gene (with 12 kinds of sequence) obtained in this study and the 57 sequences of organism RNA in the database (Fig. 1). 

  • Promotor activity - synergistic effects

    Lipopolysaccharide with IFN-γ or IL-6 exerted no synergistic effects on hBD-2 promoter activity (data not shown).

  • Radiation therapy - definitive

    Of the five CR patients who received definitive radiation therapy (one by photon radiation and four by proton radiation), four are alive with no evidence of disease at the time of writing. 

  • Radiation therapy - proton, photon

    Of the 7 of 12 patients with locoregional disease who had received no prior radiation therapy, one received the treatment followed by photon radiation and the remaining six received the treatment followed by proton radiation.

    The toxicity of definitive photon or proton radiation therapy was mild and manageable.

  • RAS activation

    Our results suggest that RAS activation induces overproduction of Epo via AT1 receptor in vivo.

  • Receptor subtype determina-tion - Ang II

    First, we determined which Ang II receptor subtypes are expressed by the spleen and bone marrow cells of wild-type (WT) mice.

  • Recommended dose

    In a previous phase I study at our institution, the recommended dose for this regimen was  determined to be 50 mg/m2 for Drug A and 30 mg/m2 for Drug B (25).

  • Relationship

    The relationship between the predictor candidates and CD34+ numbers was evaluated.

  • Response rate - age groups

    The treatment response rate was 75% (3/4) in the group aged less than 50 years, but 0% (0/8) in those over 50 (P = 0.018). 

  • Results - by culture

    Five Legionella isolates were detected in four samples from three buildings (two hotels and one office) by culture.

  • Salt bridge

    The carboxylate of compound X was shown to form a salt bridge with compound Y.

  • Selectivity

    The COX-2 selectivity of compound X, namely the COX-1 IC50/COX-2 IC50 ratio, was 0.14-0.35 (Table 1).

  • Sequence deletion - dκB

    Deletion of the dκB sequence (Δ-2187/Luc) did not alter this activity in response to lipopolysaccharide.

  • Serum ADMA concentration - statin

    Serum ADMA concentrations were significantly lower in the statin than non-statin group (P=0.007). 

  • Stochastic effects - infection

    When the stochastic effects are taken into account, together with the effects of single precautionary measures and isolation, the rapid implementation of combined measures reduces the rate of transmission and increases the probability of extinction.

  • Survival period

    The median overall survival period was 36.6 months (Figure 2).

    The median survival period for the 6 out of 12 patients with recurrent or distant metastatic disease was 16.1 months (Figure 3).

  • Survival rates

    The 1- and 2-year survival rates were estimated to be 83.3% and 53.3%, respectively.

    Among these, the 2-year survival rate was 100%, and six were still alive at the time this report was written (Figure 4).

  • Tendency to increase

    As shown in Table 2, the vehicle-treated group showed a tendency to increase gastric lesions compared with normal rats.

  • Toxicity - radiation therapy - photon, proton

    The toxicity of definitive photon or proton radiation therapy was mild and manageable.

  • Transcriptional activity - hBD-2 gene - mononuclear phagocytes

    Confers both the basal and LPS-induced transcriptional activity of the hBD-2 gene in mononuclear phagocytes.

  • TXB2 production

    Since platelets do not express COX-2, TXB2 production from whole blood platelets was used as a measure of COX-1 inhibitory activity.

  • Vehicle-treated

    Mild cartilage destruction was seen in the vehicle-treated rats, but neither Drug A nor Drug B had any effect on this change at any dose (Fig. 7, 8B).

    No differences between the vehicle-treated and drug-treated groups were seen.